Assessment of Biomarkers of Oxidative Stress among Patients with Lymphoma

Abstract

The role of oxidative stress is one of the most important factors in the development of cancer. In this study, the catalase activity and total antioxidant capacity in NHL patients were measures and compared with those in healthy subjects. The population of this study consisted of 25 patients with non-Hodgkin's lymphoma, diagnosed based on pathological findings. Total antioxidant capacity (TAC) and catalase catalytic activity (CAT) were determined by spectrophotometry.  Based on the results, the CAT activity  was significantly lower and TAC was lower (0.29±0.04 vs. 2.69±0.15; P-value=0.01) in NHL patients than in healthy subjects. The findings showed that these markers could be used as a prognosis in non-Hodgkin's lymphoma that oxidative stress may also be related to the NHL or increase the risk of disease.