Formulation and Evaluation of Lamivudine Niosomes by thin Film Hydration Technique

Abstract

Niosomes are generated from the self-assembly of hydrated amphiphilic surfactant monomers. Various nonionic surfactants belonging to different chemical classes have been found to be useful alternatives to phospholipids in assembling vesicular carriers. The terminology does suggest that distinctions exist between niosomes and liposomes. They may differ in their chemical composition, but have similar physical properties. However, niosomes may also be prepared with ionic amphiphilic like negatively charged dicetylphosphate (DCP) or positively charged stearylamine (SA) in order to achieve a stable vesicular suspension The concept of incorporating the drug into niosomes for a better targeting of the drug at appropriate tissue destination is widely accepted by researchers and academicians. Niosomes represent a promising drug delivery module. They present a structure similar to liposome and hence they can represent alternative vesicular systems with respect to liposomes, due to the niosome ability to encapsulate different type of drugs within their multi environmental structure. Niosomes are thought to be better candidates drug delivery as compared to liposomes due to various factors like cost, stability etc. Lamivudine is one of the most effective drug in the treatment of antiretroviral.

The objective of the study is to develop lamivudine niosomes containing in different concentration of surfactant by thin Rotary Evaporator. The Lamivudine Niosomes aim to treat HIV/AIDS: Inhibits the HIV transcriptase enzyme competitively and act as a chain terminator of DNA synthesis were formulated by thin film Hydration Technique using Rotary evaporator.