LI2CO3: An Catalyst for One Pot Synthesis of Α-Hydroxy Phosphonates and Study of Their Antimicrobial Activities

Abstract

The α-hydroxy phosphonates exhibit crucial antiviral, antibacterial, antifungal anti-HIV, anticancer, anti-inflammatory, anti-oxidant activities, so highly efficient and convenient protocol has been accomplished for one pot synthesis of α-hydroxy phosphonates using aromatic aldehyde, diethyl phosphite in presence of eco-friendly catalyst Li2CO3 at ambient temperature by grinding method. The grinding method is green methodology which is largely used from last decade in synthesis of various biological active compounds. The method is very facile, use of cheap, radially available and easy to handle catalyst Li2CO3 makes method more simple, reliable and practical.