Microwave Assisted Five Steps Synthesis of Substituted Pyrazines Under Solvent Free Conditions and Its Bioloical Activity

Abstract

A series of Pyrazine derivatives were Synthesized from reaction of Benzil and substituted ethanediamine dihydrochloride and sodium acetate trihydrate without solvent under the irradiation of Microwave is described.   These compounds have been characterized by 1H and13C NMR spectra and Mass spectra. In vitro antibacterial and antifungal activity have been studied for the synthesized compounds. This study reveals that compounds exhibit excellent antibacterial and antifungal activity against all the tested organisms.