A Comparison of The Top Lifestyle Changes to Prevent Alzheimer’s

Abstract

Alzheimer’s disease is a progressive neurodegenerative disorder and the leading cause of dementia globally. With no curative treatment available, there is growing emphasis on preventive strategies, particularly those rooted in lifestyle modification. This review synthesizes and compares evidence on three primary non-pharmacological interventions for Alzheimer’s prevention- diet, physical exercise, and cognitive training. Drawing on recent randomized controlled trials, longitudinal cohort studies, and meta-analyses, we explore their mechanistic pathways, efficacy profiles, and potential synergistic effects. Dietary interventions, particularly the MIND and Mediterranean diets, have demonstrated consistent associations with cognitive preservation. Aerobic and resistance exercises enhance neurovascular health and neuroplasticity, while structured cognitive training shows promise in improving working memory and executive function. Although each modality independently contributes to risk reduction, multi-domain lifestyle approaches may yield the most substantial benefits. This review highlights the importance of early implementation and sustained adherence, urging clinicians and public health stakeholders to prioritize modifiable lifestyle factors in dementia prevention frameworks.