Antioxidant Potential of Sesamol Versus Glyburide in DPPH and ABTS Assays: A Comparative In Vitro Study

Abstract

The free radical scavenging capacity of compounds is often evaluated using the ABTS assay, which measures their ability to neutralize the ABTS radical cation. Sesamol, a natural phenolic compound present in sesame seeds, has been shown to display strong antioxidant activity in both in vitro and in vivo studies.

One antioxidant that has garnered attention is glyburide, a commonly used medication for the management of type 2 diabetes. Growing evidence indicates that glyburide may also exhibit antioxidant properties, which could offer potential benefits in the prevention or treatment of osteoporosis.

Objectives:“Investigation of protective effect of sesamol and glyburide against osteoporosis in ovariectomised rats”.

Material and methods:

DPPH and ABTS method was evaluated for potential for the prevention and treatment of osteoporosis by mitigating oxidative stress.

Method: DPPH and ABTS exhibited prevention and treatment of osteoporosis activity by sesamol and glyburide. Result: Sesamol demonstrated strong antioxidant activity in both assays, showing a significantly greater free radical scavenging ability compared to glyburide.

Conclusion: These findings indicate that sesamol’s antioxidant properties may play a role in its therapeutic potential, especially in managing Oxidative stress-related conditions, including diabetes. Further research is required to explore the potential synergistic effects of combining sesamol and glyburide to enhance both antioxidant and antidiabetic efficacy.