Topical 5-Fluorouracil as an Adjuvant in Odontogenic Keratocyst –A Case Report

Abstract

Odontogenic keratocyst cyst (OKC) is a developmental odontogenic cyst that arises from remnants of dental lamina. It is an aggressive lesion. In the recent year’s attention is given to new adjunctive procedures in the treatment of OKC. 5-Flourourosil (5-FU) is an antimetabolite used in the treatment of various malignant diseases like Basal cell carcinoma. OKC is found to respond to 5-FU as it shares similar molecular etiopathogenesis with Basal cell carcinoma. A case of Odontogenic keratocyst in maxilla treated with 5–FU is presented in the paper. The ease of availability, technically simple application with reduced operative time and no local or systemic adverse effect is the advantage over Carnoy’s solution especially in OKC occurring in maxilla . The available literature is showing normal healing with no recurrence and neurosensory deficits with 5-FU application.