Amelioration of Ibuprofen Induced Hepato-Renal Injury: Biochemical and Histological Study in Rats

Abstract

Ibuprofen is one of the Non-steroidal anti-inflammatory drugs that exert anti-inflammatory, analgesic and antipyretic effects and its chronic and overuse has been associated with hepato-renal injury. The aim of this study was to know the protective effect of cyanocobalamin supplementation in amelioration of ibuprofen induced hepatic and renal injury. Twenty-eight rats were involved in this study, Group 1 (control group): rats received normal saline IP, Group 2 (IBU group): rats received 400 mg/kg ibuprofen orally by gavage for 10 days. Group 3 (IBU-cyanocobalamin treated group): rats received cyanocobalamin 1mg/kg IP 30 min before ibuprofen administration, Group 4 (IBU-cyanocobalamin treated group): rats received cyanocobalamin 1.5mg/kg IP 30 min before ibuprofen administration.

The current results showed a significant decrease of all liver and kidney parameters after treatment with two different doses of cyanocobalamin as compared with ibuprofen group. Histopathological results showed partial improvement in histological features of liver and kidney.

In conclusion, cyanocobalamin can protect the kidney and liver tissues from injury.