Potent Secondary Metabolites From Marine Sponge Extracts: Isolation, Characterization and Medicinal Applications

Abstract

Introduction: This study explores new and unique bioactive compounds from the marine sponges. This is important to do, considering the population of Indonesian sponges is abundant and diverse, By analyzing the colors of marine sponges, we graded those with bright or light colors, typically have a more complete cell structure and would contain more beneficial metabolic compounds. We successfully analyzed extracts for the presence of secondary metabolites in these marine sponges collected.

Objectives: This study aimed to identify the secondary metabolites in marine sponges collected from Indonesia with pharmaceuticals and medicinal potentials

Methods: This study employed maceration method for extract preparation. GC-MS data used for metabolic component identification, and FTIR spectra for confirmation of functional groups in organic compounds of interest.

Results: The secondary metabolite components obtained are in the form of these cholest-5-en-3-ol accounted for 25.48% of the total metabolites followed by benzenedicarboxylic acid (12.70%), pentadecanoic acid (7.89%) and Ergosta-5.22-dien-3-ol (7.78%). These substances hold potential as biomaterials for growth and stamina enhancement well as antibacterial and antifungal properties. It’s noted that marine sponges, especially those with bright or light colors (Clatria reinwardti), typically have more complete cell structure and contain more beneficial metabolic compounds. Probably there would be more diverse and abundant microbial communities associated with them. This study generate sets of data, which would be useful for follow up research in isolation, analysis and valuation of bioactive compounds such as steroids, carboxylic acids, aldehydes or their derivatives for pharmaceutical and medicinal purposes.

Conclusions: These substances are generally included in the group of carboxylic acid compounds which have the potential as medicinal biomaterials, especially to increase growth and endurance have antibacterial and antifungal properties.