Synthesis and Characterization of Compounds Related to Terbinafine Hydrochloride

Abstract

Terbinafine hhydrochloride is a drug of the allylamine derivative having a broad spectrum of antifungal activity, this is primarily used in treating skin and nails infections caused by dermatophytes. During the scale-up of the terbinafine hydrochloride process, two unknown impurities were observed and is identified. The emergence, synthesis, construal, and control of these contaminants are all covered in the current work. The production and characterization of four more impurities are also covered in this study listed in the European Pharmacopoeia 11.0 (Impurity D, E and F, and naphthalene intermediate dimer).