Comparative Evaluation of the Efficacy of Platelet Rich Fibrin Membrane Meshed with Bioactive Synthetic Bone Graft versus Bioactive Synthetic Bone Graft alone in Treatment of Human Periodontal Intrabony Defect: A Clinico-Radiographic Study

Abstract

Background: Advancing beyond conventional therapy in treatment of intrabony defects, regenerative strategies now aim for true tissue restoration. Platelet-rich fibrin (PRF), a widely used platelet concentrate has gained attention for its ability to enhance both soft and hard tissue healing through the sustained release of growth factors. Bioactive glass, a synthetic bone graft actively participates in tissue regeneration by forming a stable chemical bond with bone. This clinical study explores a novel regenerative approach by combining the biologically active properties of PRF membrane with osteoconductive potential of bioactive glass and compares its efficacy against bioactive glass used alone in the management of intrabony defect.

Materials and Methods: A total of 10 sites of intrabonydefects were selected and randomly divided into two groups. In Experimental Group (5 sites) placement of PRF membrane meshed with bioactive bone glass was done. In Control Group (5 sites) placement of bioactive glass alone was done. Clinical parameters such as plaque index (PI), gingival index (GI), pocket depth reduction(PDR), clinical attachment level gain(CAL)were recordedat baseline, 3 months and after 6 months postoperatively. Radiographicparameter, bone defect area reduction (BDR) was recordedat baseline and 6 months postoperatively.

Results: Statistically significant changes in GI, PDreduction, CAL gain, bone defect area reduction (BDR), from baseline to 6 months were seen in both groups (P < 0.05). On intergroup comparison, more favourable changes wereseen with respect to all the clinical parameters and BDR in experimental group compared to control group.

Conclusion: Within limitations ofstudy, combination of PRF membrane and bioactive glass showed a significant improvement in PD reduction, CALgain, and bone fill than bioactive glass alone.