Nanostructured Lipid Carriers for Targeted Drug Delivery: Advancements and Clinical Translation

Abstract

Nanostructured lipid carriers (NLCs) have emerged as a breakthrough in pharmaceutical nanotechnology, especially in the field of targeted drug delivery. By integrating both solid and liquid lipids into a single system, NLCs offer superior drug loading, enhanced stability, and controlled release characteristics. Their capacity to be surface-functionalized with targeting ligands allows for precise drug delivery to specific tissues or cells, reducing systemic toxicity. This paper explores the design, formulation techniques, functional mechanisms, and clinical potential of NLCs. Furthermore, it discusses recent advancements, challenges in clinical translation, and future directions in developing NLCs as next-generation therapeutic vehicles.