Clinical Efficacy of Nano-Bio-Fusion Gel as an Adjunct to Non-Surgical Periodontal Therapy in Chronic Periodontitis

Abstract

Background:

Chronic periodontitis is an inflammatory disease leading to progressive destruction of the tooth-supporting apparatus. While scaling and root planing (SRP)remain the cornerstone of therapy, residual pathogens often limit healing. This study evaluated the clinical efficacy of nano-bio-fusion (NBF) gel - a nanotechnology-based antioxidant formulation containing propolis, vitamins C and E - as an adjunct to SRP in managing chronic periodontitis.

Materials and methods:

A randomized controlled split-mouth trial was conducted on 15 systemically healthy patients aged 25–55 years with chronic periodontitis. Group a received SRP + NBF gel, and group b received SRP alone. Clinical parameters—plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL)—were recorded at baseline and 3 months post-treatment. Statistical analysis was performed using paired and unpaired t-tests.

Results:

Both groups showed significant intra-group improvement (p < 0.001) in all parameters at 3 months. Inter-group comparison revealed statistically significant reduction in GI and pd (p < 0.05) in the NBF group, while PI and CAL differences were not significant.

Conclusion:

Adjunctive use of NBF gel enhances clinical outcomes of non-surgical periodontal therapy by improving gingival inflammation and reducing probing depth. The antioxidant and bio-adhesive properties of NBF gel promote better healing, supporting its use as a promising adjunct in chronic periodontitis management.