Anticipating Pre-Eclampsia by the Assessment of the Spot Urine Albumin-To-Creatinine Ratio in Early Gestation

Abstract

Objectives: Evaluation of the spot urinary albumin-to-creatinine ratio for identifying pre- eclampsia between 20 and 28 weeks of gestation.

Study Design: Prospective observational study.

Material and Methods: In our study we included 40 pregnant women between 20 and 28 weeks of gestation, having singleton pregnancies with normal renal function, who attended the out patients Department of O&G, VIMSAR, Burla. Albumin and creatinine were estimated by auto analyser (Hitachi, Cobas c 311, Roche Diagnostics GmbH, Germany).

Result: The spot ACR ≥35.5 mg/mol yield a sensitivity of 87.71%, specificity of 95.28%, positive predictive value of 75%, and negative predictive value of 97.41% for predicting pre- eclampsia.

Conclusions: The study shown that, the asymptomatic women with eminent spot urinary ACR values in early pregnancy were more likely to develop pre-eclampsia in lateral stage. During second trimester the level of ACR level ≥35.5 mg/mmol predicted pre-eclampsia effectively before symptoms appeared. So it acts like a paradigm for assessment of this disease.