Evaluatıon of Enzymatıc Antıoxıdants ın Leukemıa Patıents ın Al-Anbar Governorate

Abstract

Background : Leukaemia patients have excessively high WBC counts in their bone marrow and blood. Symptoms of aberrant cells caused by bone marrow loss (i.e.: anaemia, neutropenia and thrombocytopenia). Infiltration (b) (e.g. liver, spleen, lymph nodes, brain, skin or testes). Aerobic organisms have a well-known antioxidant defence system. Oxidative stress causes several biochemical changes and is linked to many chronic diseases such as atherosclerosis, cardiovascular disease, mutagenesis, and cancer In mammalian cells. Recently, free radicals, particularly oxygen radicals, have been linked to the multistep carcinogenesis process. Several antioxidants have been found to prevent neoplastic.

 Aim of thesis:  In this project will be to investigate the activity of antioxidant enzymes including: superoxide dismutase (SOD), and catalase (CAT) in leukemic patients, in  Iraqi patients.

Material and methods: Our research participants through the utilization of study participants at the National Center for Hematology ,Ramadi- Teaching Hospital. Patients between the ages of 13 and 72 with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) were enrolled in the study.

there are three main divisions:

Group A (GA):  acute Lymphoblastic Leukemia (ALL) 50

Group B (GB):  acute myeloid leukemia (AML) 50

Group C (GC):  healthy control groups 50 (Controls group)

 The control group consisted of thirty-four adults ranging in age from 19 to 59, all of whom looked to be volunteers. They were divided into two groups: the experimental group and the control group. No one had any clinical or laboratory evidence that could have an impact on the parameters that were going to be evaluated.

Results : The study included the determination of the antioxidants levels  . and relationship between enzymatic correlation with leukemia patients. Patients had higher SOD activity than healthy controls (p 0.001) for ALL and AML.  The total serum catalase activity of AML and ALL patients was considerably lower than that of healthy controls (P<0.01).  The AML and ALL mean levels have grown considerably (p<0.001) for both ALL and AML had high amounts of ceruloplasmin.

Conclustions : Serum SOD activity rises significantly in both types of acute leukemia. Oxidative  stress may be a contributing factor. On the other hand, differences between AML and ALL may be related to the severity of the disease. Probably around 65 years of age.