A Facile Synthesis, Characterization and Anticancer Activity Evaluation of Benzothiazole Derivatives

Abstract

In this work novel organic based compound, Four new Benzothiazole derivatives were synthesized. The structures of the synthesized compounds were elucidated using UV,FT-IR,1H-NMR,13C-NMR, liquid chromatogram and mass spectral data. Anticancer activity of the compounds BZ-I,BZ-II,BZ-III and BZ-IV against MCF-7(human breast cancer cell line) was evaluated by using MTT assay. Cell culture studies have demonstrated significant toxicity of the compounds on the cell lines and their percentage cell viability were found. These results confirm the novel Benzothiazole derivatives may be utilized for breast cancer treatment. Furthermore, these compounds have a great potential and significance  for further investigations.