Microwave Assisted Synthesis and Biological Evaluation of Indazole Derivatives

Abstract

In this study, we synthesized indazole derivatives, including 1-H indazole and 4-chloro-1-H indazole, using microwave-assisted reactions with ortho-chlorobenzaldehyde, ortho-nitro benzaldehyde, and 2,6-dichloro benzaldehyde as starting materials. The reactions were carried out in distilled water, offering a fast and efficient synthesis process compared to conventional methods. The products were characterized through melting point determination, thin-layer chromatography (TLC), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy, confirming their structures. The antifungal activity of the compounds was tested against Candida albicans, showing promising results. This microwave-assisted approach provides a convenient and effective way to synthesize indazole derivatives with potential antifungal properties.