Invivo Evaluation of Neuroprotective Effect of Inosine Against STZ (Streptozotocin) Induced Cognitive Dysfunction in Wistar Rats

Abstract

Objective: To investigate the neuroprotective properties of Inosine against mild cognitive decline and cognitive dysfunction induced by Streptozotocin in experimental rats.

Methodology: Inosine (100, 200 & 300 mg/kg p.o.) was given once daily following the treatment of Streptozotocin (3 mg/kg i.c.v.) to male Wistar rats for 20 days. On the 1st, 10th, and 20^th days, the walking track test, locomotor activity, and object recognition test were used as behavior characteristics to assess spatial and non-spatial memory.

Results: Treatment with Inosine significantly attenuated the STZ -induced alterations in body weight, motor coordination such as locomotion, stride length, object recognition, and oxidative defense parameters. Inosine at high doses had the most prominent therapeutic effects. P<0.05 and mean ± SD are used to compare mean values with normal control, disease control, and high doses of Inosine

Conclusion: Recently, oxidative stress has been proposed as a mechanism for streptozotocin-induced neurotoxicity. Treatment with Inosine substantially decreased oxidative stress and behavioral alterations in rats treated with streptozotocin. There is a possibility for net neuroprotective benefits from inosine, which might enhance memory and learning. The anti-inflammatory and antioxidant properties of inosine may be behind its neuroprotective action.