Antibacterial Efficacy Show by Novelthiazolo-Imidazole Containing 8-Hydroxyquinoline Derivatives (HL1-HL4))

Abstract

The novel Thiazolo-imidazole containing 8-hydroxyquinoline containing derivatives (HL1-HL4) were prepared. The Metal complexes of all the four ligands, 5-(3-substituted phenyl imidazo[2,1-b]thiazol-6-yl)-8-hydroxy quinoline (HL1-HL4) were prepared by using Cu⁺²,Co⁺²,Ni⁺²_, Zn⁺² and Mn⁺² metal ions. We want to find out, Thiazolo-imidazole containing 8-hydroxyquinoline containing derivatives (HL1-HL4) has any antimicrobial activity on B. subtilis, Staphylococcus aureus, Kllebsiella promioe and E. coli. In SCDA media, every study result has demonstrated antibacterial activities against challenging microorganisms. The test results indicate that B. subtili had a greater inhibition zone (24mm) the other studied microorganisms, Staphylococcus aureus, Kllebsiella promioe and E. coli. The sample containing the chemical exhibits stronger antibacterial activity. Based on the findings of the experiment, it has been determined that the molecule found in the sample plays a significant role in pharmaceuticals, particularly in terms of its antibacterial properties.