Characterization of Primary Protein Sequence based on Rumer’s Class of Degeneracy and its Application

Abstract

Aim: The current rapid accumulation of protein sequences in various biological databases has created a challenge of analyzing their similarity and as a result, inferring evolutionary relationships across organisms.

Materials and methods: Based on Rumer's class of degeneracy, we develop a novel three dimensional (3D) representation of the protein sequence.

Results: Two enhanced mathematical invariants are used to facilitate the quantitative study of the graphical of the protein sequences. The effectiveness of our method is tested by comparing and contrasting the ND5 protein sequences of nine distinct species. A correlation and significance analysis is provided to compare our result with the previous published results.

Conclusion: The statistical finding demonstrates that our proposed method is most significant for analyzing protein sequence similarity.