Preparation and Evaluation of Andrographolide Containing Nanoparticle

Abstract

Solid lipid nanoparticles were found to be a promising approach to improve oral bioavailability of poorly water-soluble drugs which belongs to plant derived drugs. Andrographolide was selected as a model drug for the current research as it is not well absorbed topically and oral bioavailability improvement was a major challenge. The present study has shown that the SLNs being a versatile technology have the potential to improve the biopharmaceutics properties of poorly water-soluble drug i.e. andrographolide and open up new perspectives for the formulation of drugs having low aqueous solubility and high permeability. The SLN approach was used in an attempt to increase its oral bioavailability. An optimized HA-SLN4 was prepared by hot homogenization method, using phosphatidylcholine as a lipid. This was optimized on the basis of lower particle size, minimum polydispersity index, sustained drug release from SLN, lower surfactant concentration, higher solubilization of drug in the minimum amount of lipid as well as higher bioavailability. Due to entrapment of andrographolide into SLN, it permits controlled rate of drug release and showed a sustained release effect of drug.