Utilization of Heterocyclic Moieties for the Development of Anti-Microbial Agent to Combat Resistance
Main Article Content
Abstract
Antimicrobial resistance (AMR) poses a significant global health challenge, threatening the effectiveness of current treatment regimens and necessitating the development of novel antimicrobial agents. This review provides a comprehensive overview of AMR, encompassing its mechanisms, epidemiology, and societal impact. We explore the evolution of resistance in major pathogens, emphasizing the urgent need for new therapeutic strategies. Key approaches to combating AMR, including antibiotic stewardship and infection prevention, are discussed alongside promising advancements in antimicrobial drug discovery and development. The role of innovative technologies such as genomics and synthetic biology in accelerating the identification and optimization of novel antimicrobial agents is highlighted. Ultimately, this article underscores the critical importance of collaborative efforts across disciplines to mitigate the AMR crisis and ensure sustainable healthcare practices for future generations. Heterocyclic moieties are often combined with other functional groups or modified to enhance their antimicrobial activity and reduce resistance.