Study of Thyroid Function Status in Patients with Chronic Kidney Disease in a Tertiary Care Hospital of Bihar.

Abstract

Background:Chronic kidney disease (CKD) lowers kidney function, which may lead to kidney failure. Research on thyroid dysfunction in CKD patients and its effects on renal function and health is crucial. More research is investigating how thyroid abnormalities affect CKD and patient outcomes.

Objective:This study examines thyroid dysfunction inCKD patients at Patna's Indira Gandhi Institute of Medical Sciences (IGIMS), a tertiary care institution. Thyroid dysfunction and its association to chronic renal disease phases are further study topics.

Methods:A six-month hospital-based cross-sectional observational study included 100 CKD patients aged 30–70. We took morning venous blood samples to assess kidney function and thyroid profile (TSH, Free T3, and Free T4). Categorical variables were evaluated using mean, standard deviation, and Fisher's exact test; p-values less than 0.05 indicated statistical significance.

Results:Hypothyroidism was found in 45% of CKD patients. Hypothyroidism is frequent in advanced CKD, and lower GFR is associated with thyroid abnormalities.

Conclusion:The results suggest that people with CKD, especially those in advanced stages, should have regular thyroid examinations since thyroid dysfunction might worsen renal decline and affect health. Thyroid medication may benefit CKD patients, although the mechanisms need further study.