Preparation and Evaluation of Antacid Suspension using Eggshells

Abstract

Introduction: Antacids are commonly prescribed for treating gastroesophageal reflux diseases (GERD). This study aims to prepare an antacid from(eggshell) and compare its physical parameters with marketed formulation Calcium carbonate, essential for tooth and bone formation, it is used in antacid preparation. A study creates a new methodology of preparing an antacid suspension using eggshells, replacing synthetic calcium carbonate through natural biological extraction process. Previous literature indicated that no systematic scientific evaluation had been conducted on eggshell-derived antacid suspensions. Results indicated that parameters are within prescribed limits and comparable with marketed formulations.

Objectives: The objective of the study was to formulate the antacid from the natural source (eggshells) and to evaluate its physical parameters with the marketed formulation

Methods: The present study involves an attempt to extract the calcium carbonate from the eggshells through the biological extraction process. This process ensures the eggshells are safe and effective. The naturally extracted calcium carbonate that was used as an API for the preparation of the antacid suspension & it involves numerous stages like washing and the drying process for the extraction of the calcium carbonate. The eggshells are crushed and mixed with sorbitol, water, hydroxyethyl cellulose, xanthan gum, calcium carbonate, magnesium hydroxide, flavour, and sodium saccharides. The antacid suspension is then stored in a well-closed, air-tight container.

Results: The formulated suspension was compared to evaluate its physical parameters with the marketed formulation. The quantitative tests that are done to determine the presence of the calcium carbonate in the eggshells and the physical parameters that are evaluated to determine the effectiveness are within the limits for the prepared formulation are compared with that of the marketed formulation, so the prepared suspension can be proved as effectiveness as marketed one

Conclusions: The formulated suspension was found to be within the specified limit when it is compared with the marketed formulation. The formulated antacid suspension shows a better property like the marketed formulation