Formulation Development and In-Vivo, In- Vitro Evaluation of Sitagliptin Phosphate Floating Microspheres

Abstract

The purpose of the present investigation was the development and characterization of gastro-retentive floating drug delivery system for anti-diabetic drug Sitagliptin Phosphate that would retain the drug in stomach and continuously release the drug in controlled manner up to a predetermined time leading to improved bioavailability. Different formulations of Sitagliptin Phosphate were prepared as the floating microspheres using Hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 polymers by emulsion solvent evaporation technique. The dried floating microspheres were evaluated for drug content, particle size analysis, incorporation efficiency, floating behavior and in-vitro drug release studies. The developed gastro retentive floating drug delivery system of Sitagliptin Phosphate showed excellent physicochemical properties and controlled drug release pattern, thereby improving the bioavailability of the drug and also manage the complicacy of the diabetes in a better manner.