Promising Potential: The protective Effects of a Green Tea and Resveratrol Combination on Heart Function in Rodents Enduring Isoproterenol-Induced Myocardial Infarction

Abstract

When administered in large amounts, isoproterenol— a synthetic, non-selective adrenoceptor agonist— can cause severe oxidative stress and infarct-like necrosis in the myocardium. There are two types of resveratrol, a naturally occurring polyphenol: trans and cis. The cardioprotective, neurological, antidepressant, and antioxidant properties of resveratrol have been extensively studied in clinical investigations. Green tea is one of the three types of tea produced from the Camellia sinensis plant, with other varieties including oolong tea and black tea. The current study demonstrates that administering isoproterenol (ISO) to Wistar albino rats at a dosage of 85 mg/kg leads to significant cardiotoxicity. However, after a 30-day pretreatment with resveratrol-rich green tea extract, we observed cardiac protection. This treatment reversed the harmful effects indicated by levels of LDH, AST, CK-MB, and TBARS, while also increasing myocardial endogenous antioxidants such as GSH, TAC, and CAT.