Exploring the Therapeutic Potential of Nilavembu Kudineer: Phytochemical Analysis and Formulation Development

Abstract

Nilavembu Kudineer (NVK) is a traditional polyherbal formulation renowned for its potential health benefits. This study is focused on conducting a comprehensive analysis of NVK's phytoconstituents and assessing its suitability for tablet formulation. Phytochemical analysis, which included High-Performance Thin-Layer Chromatography (HPTLC) and revealed the presence of significant flavonoids and terpenoids in NVK extract. Gas Chromatography-Mass Spectrometry (GC-MS) studies identified several crucial compounds, including Andrographolide and gingerol and other compounds, contributing to its therapeutic properties. In vitro hepatotoxicity studies employing HepG2 cells demonstrated that NVK extract does not exhibit hepatotoxic effects, affirming its safety profile. Additionally, NVK extract was effectively transformed into tablets, subject to evaluation against various quality control parameters. These tablets successfully met the acceptance criteria, positioning them as a promising dosage form for NVK administration. This research offers valuable insights into the phytochemistry, safety, and formulation potential of Nilavembu Kudineer, underscoring its potential applications in both traditional and modern medicine.