Effect of Rosiglitazone in the Management of Cognitive Impairment by Exploring Its Role on Advanced Glycation End Products and Their Receptors

Abstract

Introduction

The impact of Advance Glycation Endproduct and Receptor for Advanced Glycation Endproduct is evident on various system such as vascular system and the neurological impact of it, in the recent researches it is being found that not only the molecular changes but the daily impact on Advanced Glycation Endproduct also produces neurodegeneration and cognitive impairment. We here understand the impact of Rosiglitazone being one of Peroxisome proliferator-activated receptors-γ as the saviour and also admire the action produced by it.

Methods

This animal study was conducted on the 4 different group of rats which consists of six rats in a group. The rats were induced to cognitive impairment disorder using Cisplatin, the rats were treated with the help of rosiglitazone. All the assessment was finally conducted by different parameters.

Result

The animal study for the impact of Advanced Glycation Endproducts impact on the cognitive impairment disorder and its treatment using Rosiglitazone was a successful done and changes which Cisplatin induced in a rat was nullified or reduced with the Rosiglitazone, the study was made on different parameter. The result show that the values of parameters were brought to normal with the rosiglitazone.

Conclusion

The results conclude with the positive effect of the rosiglitazone and this was evident by all the tests performed on the rats.