Evaluation of Anti-Thrombotic Activity of Clerodendrum Colebrookianum Walp in Albino Wistar Rats

Abstract

It has been widely held that Clerodendrum colebrookianum Walp was used by ancient herbalists to treat blood stagnation and inflammation. Several physiological functions have been associated with the leaves of Clerodendrum colebrookianum Walp. But their antiplatelet and antithrombotic effects are a complete mystery. Therefore, the purpose of this study is to evaluate the effects of chloroform and hydroalcoholic extracts (CBC & CBH) of Clerodendrum colebrookianum Walp leaves on platelet activity, coagulation, and thromboembolism. In an in vivo study of carrageenan-induced rat tail thrombosis, C.B.C.E. and C.B.H.E. significantly reduced thrombosis. C.B.C.E. & C.H.E. also reduced swelling and redness in the tails of rats. The antithrombotic action of the thrombosis management and its consequences in the present experimental investigation may be accounted for by the presence of flavonoids, phenolic compounds, alkaloids, glycosides, and sterols in the extract of chloroform and hydro-alcoholic (40%) solvents. Drabkin's tail bleeding experiment in rats also showed that C.B.C.E and C.B.H.E given orally provided protection. Contrasting the standard treated groups and the normal groups, the cyanmethhemoglobin method's estimates of haemoglobin level at different time intervals raises encouraging thoughts of superior anti-platelet and anticoagulant activity. Flavonoids, phenolic compounds, alkaloids, glycosides, and sterols may be responsible for the antithrombotic actions of chloroform and hydro-alcoholic extracts of C.B.C.E and C.H.E. This research suggests that CBC and CBH have therapeutic and preventive potential for cardiovascular illnesses associated with platelet hyperactivity