Preformulation Study of Mefenamic Acid

Abstract

Introduction: The preformulation study is the process of maximizing the delivery of the drug through the determination and evaluation of physicochemical properties of the new compound that could affect drug performance and development of stable, efficacious and safe dosage form. The primary step within the rational development of dosage forms of a drug substance is the Preformulation testing

Objectives: The aim of our research work is to do preformulation study and  solubility enhancement of a low water-soluble drug, that is Mefenamic drug.

Methods: We opted for the Cosolvent technique for the same, as it has high solubility in water-miscible organic solvent which  works by decreasing the interfacial surface tension between the solution and hydrophobic matter (solvent blending).

Results: Various cosolvent  hydrophilic hydrogen-bonding groups ensure water solubility, while the hydrophobic hydrocarbon regions interfere with water hydrogen bonding network, decreasing the altogether intermolecular attraction of water. By disrupting water self-association, cosolvents reduce water’s ability to squeeze out non-ionic, hydrophobic compounds, thus increasing solubility. .

Conclusions: Mefenamic acid is NSAID drug. It acts by reducing hormones which cause pain and inflammation  by inhibiting the body's production of a substance that causes fever, inflammation and pain. Due to its great effectiveness many researchers use Mefenamic acid in their research.