Synthesis and Anti-Microbial Activity of 2-(Coumarinyl-4-Oxy)-4, 6-Dichloro-1,3,5-Triazine Pyrazole-1-Carboxamide Derivatives.

Abstract

The Pyrazoline scaffold containing heterocyclic compounds are vital biological active class of organic chemistry. The literature has proven that compounds with an s-triazine core exhibiting other heterocyclic compounds frequently exhibit significant biological activities. s-triazine and pyrazoline, substituted pyrazoline are the major structural core systems found in many pharmacologically active Compounds.  In the present study, Substituted Pyrazoline derivatives are coupled with 4-hydroxy Coumarin comprising s-triazine molecule which contributes to enhance pharmacological activities of Pyrazolines. In this paper we designed and successfully synthesized new series of substituted pyrazoline and structures were confirmed by 1HNMR, IR and Mass Spectroscopy. All Synthesised compounds (9a-j) were screened for Anti-Bacterial and Anti-fungal activities.