Screening of Anticancer Compounds in Extracts of Taxus Baccata Plant

Abstract

This study investigates the anticancer potential of compounds extracted from ‘Taxus baccata’, commonly known as the European yew. Known for its bioactive taxane alkaloids, ‘Taxus’ species have contributed significantly to cancer treatment, particularly through the development of paclitaxel (Taxol), a potent chemotherapeutic agent. ‘Taxus baccata’ offers unique chemical properties that may hold untapped anticancer potential. In this study, we conducted a detailed phytochemical analysis of ‘T. baccata’ extracts, utilizing various solvents to isolate compounds. The extracts were screened for anticancer activity using in vitro assays on selected cancer cell lines, with results demonstrating notable cytotoxic effects. Further mechanistic studies revealed signs of apoptosis and cell cycle arrest, indicating potential pathways through which ‘T. baccata’ extracts exert anticancer effects. These findings support the hypothesis that ‘T. baccata’ contains compounds with therapeutic properties, reinforcing its value in cancer pharmacology. This research contributes to the ongoing exploration of plant-derived compounds as alternative and complementary treatments for cancer.