Effect of Serum Ferritin on the Prognosis of Patients with Sepsis

Abstract

Background. Sepsis is a critical condition characterized by a severe inflammatory response to infection, leading to organ dysfunction and high mortality rates. Serum ferritin, an iron storage protein, also acts as an acute-phase reactant, with levels rising significantly during inflammation. Elevated ferritin levels have been linked to worse outcomes in sepsis, potentially reflecting heightened inflammation and immune dysregulation. Understanding the prognostic role of serum ferritin could help identify high-risk patients and guide more targeted therapeutic interventions in sepsis management.

Aims : This study aims to assess the association between baseline serum ferritin levels and clinical outcomes in patients diagnosed with sepsis. We intend to explore whether elevated or reduced ferritin levels correlate with the severity of sepsis and overall patient prognosis.

Methods. This research was conducted as a comparative study over a duration of one year at Murshidabad Medical College, Department of General Medicine. 100 patients were included in this study

Result. In survival 40 (40%)and non-survival 60 (60%)patients had Respiratory system it was statistically not significant (P=0.0455)In survival 80 (80%)and non-survival 20 (20%)patients had Urine system it was statistically not significant (P=1.9701)In survival 66 (66%)and non-survival 34 (34%)patients had Blood system it was statistically significant (P=0.00137)In survival 66 (66%)and non-survival 34 (34%)patients had Serum iron (μg/dL)it was statistically significant (P=0.00137)In survival 70 (70%)and non-survival 30 (30%)patients had Transferrin (mg/dL)it was statistically not significant (P<0.0001).

Conclusion: High-level serum ferritin was an independent prognostic marker for the prediction of mortality in patients with sepsis. Further high-quality research is needed to confirm the relationship between ferritin and the prognosis of septic patients