Synthesis Characterization, Biological Evaluation of Acetyl Substituted Heterocyclic Isatin Derivatives

Abstract

Isatin-1H-Indole-2,3-dione and its derivatives are group of indole derivatives that contain one nitrogen at the first position and two ketone groups at second and third position and is able to involve in electrophilic and nucleophilic substitution reaction at various positions.

In this research Acetyl substituted Isatin products are prepared. It is a broad range of heterocyclic molecule that can be used as precursor for drug synthesis and research in the discipline of pharmaceutical chemistry. The chemical compounds can be identified using chemical tests. Structures of acetyl substituted heterocyclic compounds can be confirmed by IR, NMR, MASS spectroscopy. Acetyl substituted heterocyclic Isatin derivatives has broad spectrum of activity against fungi, helminthes, mycobacterium, HIV virus and also possesses anti-hypertensive, anti-parkinsonism, anticonvulsant and anti-oxidant activity.

A new series of Isatin molecules were synthesized from aniline, chloral hydrate and hydroxyl amine to form intermediate isonitrosoacetanilide that was further treated with sulphuric acid to give Isatin.