Antiulcer Activity of the Ethanolic Extract from Citrus Limetta peels in the Ethanol Induced Ulcer Model in Swiss Albino Mice

Abstract

Peptic ulcer disease (PUD) is a common gastrointestinal disorder marked by ulcers in the stomach or duodenum. While numerous pharmacological treatments exist, there is growing interest in natural products and their bioactive compounds for their potential therapeutic advantages. This investigation examinesthe use of Citrus limetta peels extract in managing peptic ulcers, focusing on research conducted with Ethanol Induced Ulcer Model using Swiss Albino Mice. The standard of reference was Pantoprazole. Ethanol was used to induce ulcer in Mice. Peel extract of this plant may be a natural product useful in prevention and treatment of gastric lesions, acting by different mechanism.Citrus Limetta contains compounds like limonene ,bergamol, linalool. These constituents show the necessary for Anti-Ulcer effect.the monoterpene limonene are widely used flavoring agents that are found in some common food items also.This is also used medicinally throughout the world to treat gastritis and gastric disorders. The Limoneneprovided effectivegastroprotection against lesions induced by absolute ethanol and NSAID (non-steroidal anti-inflammatory drug) .limonenedo not interfere with gastric H⁺ secretion, serum gastrin or glutathione (GSH) level in gastric mucosa.