"Stem Cell-Based Strategies for Dental Tissue Regeneration: Advances, Molecular mechanisms, and Future Perspectives"
Main Article Content
Abstract
Stem cell therapy for dental tissue regeneration is another innovation in regenerative dentistry providing new treatment methods for dental tissue defects caused by a disease or injury. This review gives a concise description and comparison of the various stem cells that are useful in dental tissue engineering; dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), and periodontal ligament stem cells (PDLSCs). The review presents the main aspects of stem cell-mediated tissue repair and regeneration, such as signalling pathways, the role of extracellular matrix (ECM), and scaffold biomaterial effects. Recent clinical uses of tissue engineering and stem cells in the dental field including pulp/periodontal regeneration right up to total tooth complex bioengineering are reviewed. Furthermore, the review explicates the issues and concerns linked with stem cell therapies and also discusses the future research that may bring about the improvement of stem cell therapies in terms of efficiency and safety. The areas where CRISPR, 3D bioprinting, and nanotechnology are incorporated are also considered to discuss their applicability in dental tissue regeneration.