Formulation Development and Evaluation of Eugenol Base Dental Gel for Periodontitis
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Abstract
The purpose of the study was to develop and evaluate a dental gel using eugenol as its primary component for the treatment of periodontitis. It is chosen for the treatment of periodontitis because it has a broad spectrum of antibacterial activity against a variety of periodontal infections. In order to formulate eugenol gel, PBC Carbomer 940 is used as a gelling agent, eugenol is used as a medicinal agent, Propanediol is used as a co-solvent, methyl paraben is used as preservative, and the necessary amount of distilled water is used as the vehicle. The eugenol was evaluated for acid value, ester value, specific gravity and refractive index and it shown satisfactory results. The prepared gel was evaluated for antimicrobial activity, pH, spreadability, extrudability, drug content etc. The eugenol dental gel formulations was tested against, Lactobacillus acidophilus, Pseudomonas aeruginosa and Eschericha coli and compared with other formulations. Antimicrobial activity demonstrated that the formulation EDG3 is a suitable dosage form for the treatment of periodontitis.