Computational Analysis and Molecular Modelling of Tryptophan Synthatase as Novel Antifungal Drug Target Against Bioactive Compounds of Punica Granatum.

Abstract

Fungal infections are a major worldwide health concern due to the rise in immunocompromised people with weakened immune systems. Invasive aspergillosis, an infection caused by fungi of the Aspergillus species, is the leading cause of invasive aspergillosis. Even with the development of new, potent antifungal medications, invasive aspergillosis still has a death rate above 40%. To address this, researchers have turned to herbal substances, mostly phytochemicals, in an effort to produce safe and commercially feasible antifungals. Pomegranates have long been recognized for their therapeutic benefits, and their chemical components have raised research interest in recent years. The goal is to find a phytochemical present in pomegranate which acts as inhibitor of novel drug target tryptophan synthase of Aspergillus fumigatus.