Effect of Body Mass Index (BMI) On the Levels of Spexin Hormone, Growth Hormone, And Leptin Hormone in Some Infertile Women in Mosul City

Abstract

This study was conducted to determine the extent of the impact of body mass index (BMI) on certain biochemical variables in obese women suffering from infertility. A total of 30 blood samples were collected from women diagnosed with primary and secondary infertility, along with 10 blood samples from healthy women without any fertility issues, serving as the control group. The samples were divided into three groups based on body mass index (BMI): BMI 1 (19-24) kg/m², BMI 2 (25-30) kg/m², and BMI 3 (32) kg/m² or higher. The results of the study, following statistical analysis, demonstrated a significant decrease in the levels of Spexin hormone at a probability level (P ≤ 0.01) in obese women suffering from infertility. The most noticeable decrease was observed within the BMI 3 group compared to the Control group. Similarly, the results indicated a significant reduction in the concentration of Growth hormone at a probability level (P ≤ 0.01) in obese women, with the highest decrease seen in the BMI 3 group compared to the Control group. On the other hand, the results showed a significant increase in the concentration of Leptin hormone at a probability level (P ≤ 0.01) as body mass index (BMI) increased. The highest increase in hormone concentration was observed in the BMI 3 group. These findings clearly demonstrate an inverse relationship between BMI and Spexin hormone, as well as BMI and Growth hormone, while indicating a positive correlation between BMI and Leptin hormone levels in the bodies of obese, infertile women.