Exploring the Role of Mandukparni (Centella Asiatica (L.) Urban) As Antifungal Agent Via Phytosomes Technology as a Novel Approach in Drug Discovery in Targeted Treatment of Fungal Infection in Type II Diabetes Mellitus

Abstract

Type II Diabetes Mellitus (DM) is one of the diseases in metabolic triad syndrome categorized in Lifestyle Disorders. Patients suffering from Type II Diabetes Mellitus often manifest themselves with fungal infection of skin, which is a recurrent infection requiring extensive treatment and hence, requires newer drug discoveries to curb the same. In the same line, Charak Samhita explains, causes of diseases due to metabolic derangement which includes Type II DM and advocates predominant use of herbs possessing bitter taste. With this background, the herb Mandukparni (Centella asiatica (L.) Urban) growing in marshy habitat and is known to harbor endophytic fungus on itself through symbiosis leads to production of secondary metabolites by establishing biochemical communication; Primarily known for its cognitive effect, but this herbal drug remains unexplored in its action as an antifungal agent in patients of fungal infection in Type II Diabetes Mellitus. To understand this concept, the exact mechanism of perception of Mandukparni, its bitter taste on skin requires a detailed enquiry. Moreover, the action of Centella  via Phytosomes technology in curbing the fungal infection could be possible way for new drug discovery to treat such patients. This review is a comprehensive learning of probable mode of action of Mandukparni (Centella asiatica (L.)Urban)  growing the endophytic fungus leading to generation of secondary metabolites as antifungal agents and its application via phytosome technology in exploring as a new drug discovery in treatment of Fungal infection  in Type II DM.