Comparative Study on the Use of Vancomycin Powder in Spine Fixation Surgery for Prevention of Post-Operative Infection

Abstract

Introduction: Spine surgery is associated with a wide range of com-plications. Surgical site infections are the most devastating complications because they are associated with low postoperative recovery, low patient satisfaction, and high patient morbidity and mortality. In the literature, infection rates of spine surgeries range from 0.7% to 11.9%.

Aims: To study  the difference in the rate of post-operative infections with and without the use of Vancomycin powder in spine fixation surgery.

Materials and Methods: It was a Comparative study between the In Risk group and In Risk with  Vancomycin group.Each group had 25 patients each as per simple randomization.   This study was conducted from February 2024- August 2024 at the department of Neurosurgery, KPC Medical College.

Result: In Risk with control, 3(12%) patients had SSIs, 4(16%)patients had Superficial SSIs, 2(8%)patients had Deep SSIs, 3(12%)patients had Dose of 1 g, 1(4%)patient had Dose of 2 g, 2(8%)patients had Dose between 0.5 –and 2 g, 3(12%)patients had Cervical, 2(8%)patients had Thoracolumbar, 1(4%)patient had Infectious bacteria, 1(4%)patient had MRSA, 2(8%) patients had Gram-positive bacteria and 1(4%) patient had Gram-negative bacteria.In Risk with vancomycin, 4(16%)patients had SSIs, 2(8%)patients had Superficial SSIs, 1(4%)patient had Deep SSIs, 2(8%) patients had Dose of 1 g, 3(12%) patients had Dose of 2 g, 1(4%)patient had Dose between 0.5 –and 2 g, 2(8%)patients had Cervical, 2(8%)patients had Thoracolumbar, 1(4%)patient had Infectious bacteria, 3(12%)patient had MRSA, 1(4%)patient had Gram-positive bacteria and 3(12%)patient had Gram-negative bacteria. Association of Outcomes with Group was not statistically significant (p=0.92059).

Conclusion: There was no statistically significant difference in the rate of infections post spinal surgery, in the In Risk group without the use of Vancomycin powder and the In Risk group with vancomycin powder.