Testicular Energy Metabolism Impairment and Dyslipidemia Induced by Cadmium Chloride in Rats: Ameliorative Effect of Polyherbal Remedies, STC30 and PurXcel.

Abstract

Introduction: Exposure to Cadmium is associated with oxidative stress. PurXcel and STC30 are polyherbal remedies rich in antioxidants. Their effects on Cadmium-induced dyslipidemia and impaired testicular energy metabolism are unknown.

Objectives: To achieve our aim, testicular energy metabolism ((lactate, pyruvate, fructose) and serum lipid profile were assayed.

Methods: Thirty five male wistar rats were randomly assigned into seven groups of five rats each, control, Cadmium-only, PurXcel-only, STC30-only, Cadmium+PurXcel, Cadmium+STC30 and Cadmium+PurXcel+STC30. The duration of daily administrations was 28 days.

Results: Testicular concentrations of fructose, pyruvate and lactate were significantly reduced in the Cadmium-only group compared with the control but which was higher in all PurXcel or STC30-treated groups whether singly or in combination with Cadmium than in the Cadmium-only group. Serum total cholesterol and triglyceride were increased in the Cadmium-only group compared with the control but lower in the PurXcel-only, STC30-only and in the Cadmium+PurXcel+STC30 than in the Cadmium-only groups. The high density lipoprotein cholesterol in the Cadmium-only group was decreased compared with the control but higher in all PurXcel or STC30-treated groups than in the Cadmium-only groups. Low density lipoprotein cholesterol was increased in the Cadmium-only group compared with the control though lower in all PurXcel or STC30-treatment groups, singly or in combination with Cadmium in the Cadmium-only group.

Conclusion: Cadmium-impaired testicular energy and lipid metabolisms are ameliorated by PurXcel or STC30, which if administered singly to normal rats have no significant effects on testicular energy or lipid metabolism.