Modified Drug Delivery of Steroids in Oral Lesions

Abstract

This Narrative Review investigates the advancements in steroid therapy for managing oral lesions through innovative drug delivery systems. Oral lesions, such as aphthous ulcers, oral lichen planus, and pemphigus vulgaris, pose significant therapeutic challenges due to their chronic nature and the potential systemic side effects of conventional steroid treatments. This review comprehensively examines current and emerging modified drug delivery methods designed to optimize the local administration of steroids, enhancing therapeutic efficacy while minimizing systemic exposure and side effects.

The review explores into various innovative delivery systems, including bioadhesive formulations, mucoadhesive patches, and nanoparticle-based carriers, each offering unique advantages in targeting and sustained release of steroids within the oral cavity by enhancing local drug concentration and prolonging drug action at the lesion site, these technologies aim to improve clinical outcomes and patient adherence to treatment protocols.

It also highlights the pharmacokinetics, clinical efficacy, and safety profiles of these advanced delivery systems and also discusses the practical implications of these findings  and outlines potential future directions for research and development in this area.

Overall, this narrative review emphasizes the critical role of innovative drug delivery systems in the effective management of oral lesions with steroids, advocating for continued exploration and refinement of these approaches to enhance patient care in dentistry