Anticancer Evaluation of Some Novel 2-Azetidinone Benzothiazole- Derivatives

Abstract

Insearch of potential therapeutics for cancer, we designed and synthesized some novel 2-azetidinone-benzothiazole derivatives by facile method. These designed series were denoted by PN1-PN5. Physicochemical properties of designed compounds were evaluated by insilico studies with the help of Swiss ADME, and Molinspiration. Lipinski rule of five parameters were predicted by Swiss ADME, and Bioactivity scores were predicted by Molinspiration. The results showed that all compounds demonstrated good drug likeness score. The synthesized compounds were characterized by IR, NMR and Mass spectrometry. Five novel derivatives were screened for invitro anti-cancer activity by MTT assay method. Among all the synthesized compounds compound PN4 showed equipotent activity than standard Gefitinib. This data suggested that these compounds might be promising for further research and development in cancer drug designing.