The Correlation between 25-Hydroxyvitamin (OH) D Levels and Anemia in Paediatric Patient under 6 Years Old with Family History of Atopy

Abstract

Introduction: Children atopic disease is associated with anemia because multiple comorbid chronic inflammation can lead to anemia. In other hand, there was association between Vitamin D and anemia. Children with atopic disease also could run into vitamin D deficiency.

Objectives: The prevalence of low Vitamin D level in atopic children found to be higher than healthy children. Lack of Vitamin D and anemia in children, especially those with atopy disease, will affect their growth, development, and immunological functions. Therefore, this study investigates the relationship between 25-hydroxyvitamin D (OH) D levels and anemia in pediatric patients with a family history of atopy.

Methods: A Cross sectional study with purposive sampling in Diponegoro University Hospital, Semarang, Indonesia from June – October 2021, a total of 78 pediatric patients aged 6 months - 6 years meeting the inclusion criteria were enrolled in the study.

Results: Both subject with deficiency 25(OH)D levels and anemia was found in 3,8% patients. The result showed from nutritional diary analysis (3 days food recall) that most of the pediatric patients had deficient level of iron (62.8%) and calories (62.8%) intake, but most of them also had sufficient intake of zinc (85.9%), protein (98.7%), and fat (52.6%).

Conclusions: There was no correlation between 25(OH)D levels and anemia in subjects, also between nutrition intake and type of atopic disease with anemia in subjects. This is likely because the association is multifactorial in nature. Further research is warranted to elucidate the underlying mechanisms and clinical implications of this results.