The Role of Insulin Resistance and Glucose Metabolism in Women with Pcos

Abstract

Background: PCOS (Polycystic ovarian syndrome) has been a widespread endocrine disorder in women of reproductive age, categorized by multiple factors contributing to its development. It is linked to issues with the menstrual cycle and reduced fertility. The menstrual dysfunction associated with PCOS is caused by either anovulation or oligo-ovulation. It leads to the cessation of menstruation, resulting in infrequent or irregular menstrual periods. PCOS is frequently accompanied by hyperinsulinemia and insulin resistance. Our study involves the estimation of PPBS (postprandial blood sugar) and FBS (fasting blood sugar) levels in patients with PCOS to gain insights in the metabolism of glucose in PCOS.

Aims & Objective:To understand how younger adult groups' glucose metabolism is affected by PCOS.

Materials and Methods:A case-control researchhas been performed on 50 patients with PCOS aged between 18 and 45 years, and 200 healthy women with regular menstrual cycles. The control group was carefully selected to match the PCOS group in terms of age and physical measurements. The statistical analysis has been performedbyutilzing a student's t-test.

 Results:The levels of FBS& PPBShave been substantially greater in women with PCOS while comparing to women who are suffering from regular menstrual cycles after a 2-hour OGTT.

Conclusion:Patients with PCOS have a higher susceptibility to developing IGT (Impaired Glucose Tolerance) and T2DM (Type 2 Diabetes Mellitus). To avoid complications, it is advisable to conduct screenings for impaired glucose tolerance and T2DM.