A Study on Drug Release Kinetics of Fexofenadine Hydrochloride and Montelukast (Monti-FX) Tablets with Application of Mathematical Models and Evaluation of their Bioactivity

Abstract

The aim of the present proposed research work is to use mathematical models to studythe drug release kineticsin tablet matrix. A research is carried out using Fexofenadine and Montelukast tablets, 120 mg/10 mg.Drug release profile is carried in Hexane and Phosphate bufferin the time intervals of 0,10,20,30,45,60 and 75hoursrespectively.Toget a better idea about the drug release kinetics, numerous mathematical models, including the Zero order, First order, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas have been proposed. The high degree of correlation coefficient between the drug release profiles of fexofenadine and montelukast tablet serves as the basis for selecting the best model. Additionally, it has been determined that the medication release pattern of Fexofenadine and Montelukast, is best fitted withZero order model and follows Zero order drug release kinetics in both hexane and phosphate buffer. The bioactivity of the drug has also been evaluated against gram-positive, gram-negative bacterial species and fungal species and found activity in combined form of Mont-FX.