Study of the Anticonvulsant Effects of Aconitum Heterophyllum Root Extract

Abstract

This research was conducted to learn more about the effectiveness of an Aconitum heterophyllum root extract in inhibiting convulsive activity. Aconitum heterophyllum, a member of the Ranunculaceae family, is a popular Ayurvedic herb for its purported health benefits. The experiments conformed to accepted protocols. Antioxidant, anticonvulsant, and neurotransmitter levels in vivo were investigated with an Aconitum heterophyllum chloroform extract. Both the maximal electroshock induced convulsion and the pentylenetetrazole induced convulsion models were used to assess CEAH's anticonvulsant efficacy. Both MES and PTZ were compared to their respective standards, diphenylhydantoin and sodium valproate, respectively. Antioxidant and anticonvulsant properties were increased in extract-treated animals in vivo. Their neurotransmitter levels were likewise significantly elevated. CEAH's anticonvulsant action was comparable to the gold standards, albeit weaker. The presence of chemical components such diterpene alkaloids may be responsible for the outcome; either individually or in combination, these compounds increased the plant's anticonvulsant efficacy, lending credibility to Aconitum heterophyllum's traditional medical uses. This research lends credence to the idea that this herb should be incorporated into treatments for epilepsy.