Mangiferin Bioactive Roles in the Treatment of Lung Cancer

Abstract

Mangiferin, a natural chemical present in many plants such as mango trees, is being studied for its potential in cancer therapy. Studies indicate that mangiferin, either by itself or in conjunction with other anticancer drugs, demonstrates potential in combating lung, brain, breast, cervical, prostate cancers, and leukemia. It has antioxidant and anti-inflammatory properties. Mangiferin, derived from several parts of the mango plant, possesses multiple health benefits such as antioxidant, antibacterial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory effects. It inhibits peroxisome proliferator activated receptor isoforms, which helps guard against various cancers like lung, colon, breast, and brain tumors by reducing tumor necrosis factor α production, decreasing inducible nitric oxide synthase, and increasing apoptosis. In this review under covered all the therapeutic roles of mangiferin, their mechanism and other reported research work.