Comparative Effect of Norepinephrine and Phenylephrine on Hypertension During a Caesarean Section

Abstract

Studies have been proving since ages that NE is a potent agonist of adrenergic receptors; however, in contrast to PE, it also exhibits a mild agonistic effect on adrenergic receptors. NE may be considered a viable vasopressor option for the purpose of sustaining blood pressure levels during spinal anesthesia. It exhibits a reduced propensity to decrease HR and CO in comparison to PE. Thus, the goal of this study was to analyze and evaluate the impact of NE on individuals with high blood pressure in an ECS condition. A comprehensive preanesthetic examination was conducted, which included the recording of SBP,DBP,HR,MAP,O2 saturation and ECG for all the patients included in the study.Furthermore, the parameters were recorded at different times, following which a reading was taken. The analysis of repeated measurements using the GLM revealed that there were no statistically significant differences in the mean HR after surgery among the different groups (p = 0.594), SBP (p = 0.315), and ABP (p = 0.926), respectively. As a result, it was clear that NE is better than PE in terms of its hemodynamic effects in preventing spinal anesthesia-induced hypotension during elective C-delivery, as NE shows better preservation of maternal HR and less need for additional vasopressor medication. Importantly, neither NE nor PE had any negative impacts on neonatal or maternal health.